What is literature survey
NMDA receptor antagonist and GABAA what is literature survey modulatory properties.
It first became available in Europe in 1984 under the brand name Katadolon and after it went off patent many generic brands were introduced. Flupirtine is used as an analgesic for acute pain, in moderate-to-severe cases. In 2013 due to issues with liver toxicity, the European Medicines Agency restricted its use to acute pain, for no more than two weeks, and only for people who cannot use other painkillers. The most serious side effect is frequent hepatotoxicity which prompted regulatory agencies to issue several warnings and restrictions.
Flupirtine is devoid of negative psychological or motor function effects, or effects on reproductive function. Although some studies have reported flupirtine has no addictive properties, there was suggestion that it may possess some abuse potential and liability. There were at least two registered cases of flupirtine abuse. Flupirtine is a selective neuronal potassium channel opener that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties. Flupirtine was discovered and developed between the 1970s and the 1990s by Chemiewerk Homburg in Frankfurt am Main, Germany, which became Degussa Pharma Group and then through mergers, ASTA Pharma and Asta Medica. It was approved for the treatment of pain in 1984 in Europe under the brand name Katadolon.
As of 2013 it was used in 11 member countries: Bulgaria, Estonia, Germany, Hungary, Italy, Latvia, Lithuania, Poland, Portugal, Romania and Slovak Republic. Many generics entered the European market around 2011. What is literature survey was never introduced to the United States market for any indication but in 2008, Adeona Pharmaceuticals, Inc. In 2010 retigabine was approved by the FDA as an anticonvulsant for the treatment of refractory partial-onset seizures in treatment-experienced patients. As of 2016 it is marketed under many brand names, including Efiret, Flupigil, Flupirtin, Flupirtina, Flupirtine, Flupizen, Fluproxy, Katadolon, Metanor, Trancolong, and Zentiva. Jakob disease, Alzheimer’s disease, and multiple sclerosis.
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Flupirtine underwent a clinical trial as a treatment for multiple sclerosis and fibromyalgia. Quantitation of flupirtine and its active acetylated metabolite by reversed-phase high-performance liquid chromatography using fluorometric detection». Investigation of the in Vitro Metabolism of the Analgesic Flupirtine». Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment». Retigabine: Chemical Synthesis to Clinical Application». European Medicines Agency — Human medicines — Flupirtine-containing medicinal products».
Clinical experience with flupirtine in the U. Mædica — A Journal of Clinical Medicine. Evaluation of the Abuse Potential of the Novel Analgesic Flupirtine Maleate». Abuse Potential and Physical Dependence Liability Studies with Flupirtine Maleate in Laboratory Animals». Abuse Liability of Flupirtine Revisited: Implications of Spontaneous Reports of Adverse Drug Reactions».
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